Contrasting Mutation Rates from Specific-Locus and Long-Term Mutation-Accumulation Procedures
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چکیده
منابع مشابه
Contrasting Mutation Rates from Specific-Locus and Long-Term Mutation-Accumulation Procedures
Until recently, the two predominant ways to estimate mutation rates were the specific-locus method and the mutation-accumulation (Bateman-Mukai) method. Both involve seeding a number of parallel lines from a small, genetically uniform population, growing as long as is feasible but not so long as to allow selection to perturb mutant frequencies, and sometimes using extreme bottlenecks to facilit...
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Relative per-locus mutation rates for Y-DNA microsatellites, and also for mitochondrial DNA singlenucleotide polymorphisms, can be estimated directly from diverse collections of haplotypes without segregating population components. The calibrated average mutation rates for the FTDNA panels of 12, 25, and 37 loci are 0.00187±0.00028, 0.00278±0.00042, and 0.00492±0.00074, respectively, from a col...
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Recent studies of somatic and germline mutations have led to the identification of a number of factors that influence point mutation rates, including CpG methylation, expression levels, replication timing, and GC content. Intriguingly, some of the effects appear to differ between soma and germline: in particular, whereas mutation rates have been reported to decrease with expression levels in tu...
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ژورنال
عنوان ژورنال: G3 Genes|Genomes|Genetics
سال: 2012
ISSN: 2160-1836
DOI: 10.1534/g3.111.001842